Luncheon Symposia Series

Complimentary lunch provided by ARRS for up to 200

Tuesday, April 24, 12:15–1:15 pm

A Review of the Safety of Gadolinium-Based Contrast Agents in Pediatric Imaging


FACULTY: Shannon G. Farmakis, M.D., Assistant Professor of Radiology and Pediatrics, Medical Director of Pediatric Radiology, St. Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital

Contrast-enhanced MRI has become an increasingly utilized imaging modality in the pediatric population.  Familiarity with the safety profiles of the various gadolinium-based contrast agents (GBCAs) and approved indications is important in managing this group of patients.  The unique pharmacologic and imaging characteristics of certain GBCAs may have a role in agent selection.    

A number of recent studies in the adult and pediatric literature have described areas of high signal intensity in the globus pallidus and dentate nucleus in patients with a history of multiple prior exposures to GBCAs, and some studies have found gadolinium in tissue specimens of these areas.  There is a growing concern about the implications of these findings of gadolinium deposition by various governing bodies, regulatory authorities, physicians, and patient groups.

While currently there is no direct evidence that links gadolinium deposition with specific symptoms or syndromes, further research into the safety of the various types of agents (linear versus macrocyclic) is warranted and is supported by the American College of Radiology.  There are also implications for changes in practice, such as reporting cumulative gadolinium dosages in reports.  

Up to 1 CME credit available.

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The Institute for Advanced Medical Education (IAME) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The Institute for Advanced Medical Education (IAME) designates this enduring material for a maximum of 1 AMA/PRA Category 1 CME Credit.™. Physicians should only claim credit commensurate with the extent of their participation in the activity.