Concentration Differentiates Lung Cancer from Pulmonary Metastases
Leesburg, VA, January 11, 2023—According
to an accepted manuscript published in ARRS’ American Journal of Roentgenology (AJR), ringlike
peripheral high iodine concentration maps from dual-energy CT (DECT) can help
guide management in patients with known lung cancer and an indeterminate
peripheral high iodine concentration had excellent interobserver agreement,
showed high specificity (albeit poor sensitivity) for differentiating pulmonary
metastasis from primary lung cancer, and independently predicted pulmonary
metastasis,” wrote AJR first author Yoshinao Sato, MD, PhD, from
the Diagnostic Imaging Center at Japan’s Cancer Institute Hospital in Tokyo.
AJR accepted manuscript
study included 93 patients (64 men, 29 women; median age, 70 years) who
underwent resection of a primary lung cancer (n=68) or pulmonary metastasis
(n=25) corresponding with a solid lesion on preoperative contrast-enhanced DECT
performed between April 2020 and March 2021. After constructing venous-phase
120-keV single-energy images, equilibrium-phase 66-keV virtual monoenergetic
images, as well as iodine concentration maps, two radiologists independently
assessed lesions for the following: spiculated margins, air bronchograms, rim
enhancement, and thin ringlike peripheral high iodine concentration.
peripheral high iodine concentration on DECT showed excellent interobserver
agreement (κ=0.80), and had sensitivity of 52% and specificity of 81% for
differentiating pulmonary metastases from primary lung cancers. Additionally, the
finding independently predicted pulmonary metastasis in multivariate analysis
[OR=7.81, 95% CI: 2.28–29.60; p=.001] combining patient and lesion
concentration maps from DECT could help determine the diagnosis for lesions
that are equivocal for pulmonary metastasis on conventional images,” the
authors of this AJR accepted manuscript reiterated.
first radiological society, the American Roentgen Ray Society (ARRS) remains dedicated to the advancement
of medicine through the profession of medical imaging and its allied sciences.
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Logan K. Young, PIO
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