Outcome Predictive Performance of Admission Chest Radiographs in COVID-19 Patients

Leesburg, VA, April 18, 2021—A Scientific E-Poster to be presented at the 2021 ARRS Virtual Annual Meeting found that in the setting of a high pretest probability of COVID-19 infection or with a quick turnaround of the rapid real-time reverse transcriptase–polymerase chain reaction (RT-PCR) COVID-19 test, a chest x-ray (CXR) scoring system may be used prospectively to predict patient outcomes.

“We developed an accurate and reliable tool for classifying COVID-19 severity, which can be used both at the attending chest radiologist and junior resident level. This study identifies the laboratory, clinical and radiographic data that predict important patient outcomes such as death, intubation, and the need for chronic renal replacement therapy (CRRT),” wrote first author Russell Reeves of Thomas Jefferson University in Philadelphia, PA.

Reeves and colleagues identified patients with nucleic acid-confirmed COVID-19 admitted to an urban multicenter health system from March 16 to April 13, 2020. Three cardiothoracic radiologists and three diagnostic radiology residents then independently scored their admission CXRs, based on extent and severity of COVID-19 pneumonia. Demographic variables, clinical characteristics, and admission laboratory values were collected, while interrater reliability among attending, resident, and the combined group of graders was assessed.

Of the 240 patients (142 males, 98 females; median age, 65 years) who met the inclusion criteria, interrater reliability for CXR scoring was high (mean, 0.686) among the attending, residents, and combination of graders. Furthermore, there was no difference in outcomes across gender, race, ethnicity, or those with either a history of lung cancer or chronic obstructive pulmonary disease. Although CXR severity proved an independent predictor of death (p < 0.001), CXR severity was a non-independent predictor of CRRT (p = 0.007) and intubation (p < 0.001) but not extracorporeal membrane oxygenation. 

“These findings are supported by prior work, validating the utility of CXR for patient prognostication, while adding new insight into COVID-19 infection during the initial presentation,” the authors of this ARRS Annual Meeting E-Poster concluded.

Founded in 1900, the American Roentgen Ray Society (ARRS) is the first and oldest radiological society in North America, dedicated to the advancement of medicine through the profession of radiology and its allied sciences. An international forum for progress in medical imaging since the discovery of the x-ray, ARRS maintains its mission of improving health through a community committed to advancing knowledge and skills with an annual scientific meeting, monthly publication of the peer-reviewed American Journal of Roentgenology (AJR), quarterly issues of InPractice magazine, AJR Live Webinars and Podcasts, topical symposia, print and online educational materials, as well as awarding scholarships via The Roentgen Fund®.